BioCreatine™ Optimal Creatine Complex
BioCreatine™ provides the proven mental and physical benefits of creatine monohydrate plus the unique advantages of Himalayan Pink Salt and Fenugreek Extract.
Research suggests that these compounds can help transport creatine into the brain and body without having to consume simple carbohydrates.
The benefits of BioCreatine™ include:
- Mental energy and improved working memory
- Lean muscle growth, stamina, and hydration
- Neuroprotection and anti-aging
Designed for optimal absorption and performance, BioCreatine™ is the the most effective creatine supplement on the market.
Enhances muscle growth and repair†
Supports recovery & physical performance†
Promotes skin elasticity and strong connective tissue†
Supports healthy cell regeneration and joint protection†
Ingredients
Suggested Use
Take 1-2 servings per day with water, or as directed by a healthcare practitioner. BioCreatine™ can help provide ATP energy to maintain CILTEP’s benefits of accelerated learning and extended concentration.
BioCreatine™ requires no loading or cycling and does not cause bloating.
U.S.A. manufactured in a cGMP facility. Natural Stacks proudly uses only the highest quality ingredients.
How It Works
Creatine is best-known for it’s ability to improve muscle gains and overall physical performance. Many people aren't aware that supplementing with creatine can also significantly boost brain power. It’s been demonstrated to enhance cognition, delay mental fatigue. improve neuroprotection, and promote anti-aging.
Himalayan Pink Salt is included in BioCreatine™ to optimize sodium levels for maximum creatine uptake. Fenugreek extract is added to enhance creatine’s absorption, comparable to rates studied when creatine is co-ingested with a simple carbohydrate source.
Creatine Monohydrate
Creatine is a naturally occurring amino acid that helps supply energy to cells, especially muscle cells. [1]
It acts like a battery by storing ATP (adenosine triphosphate) that the cells can use as fuel at any time. [2] Creatine supplementation increases the size of your battery so that you can sustain long-lasting mental energy or quickly recover from a workout.
Creatine is best-known for it’s ability to improve muscle gains and overall physical performance. [3-6] Many people aren't aware that supplementing with creatine can also significantly boost brain power. It’s been demonstrated to enhance cognition [7-10], delay mental fatigue [11], improve neuroprotection [12,13], and promote anti-aging. [14,15]
In its natural state creatine can be found in foods like beef and pork, although most of it gets broken down during cooking.
A double-blind, placebo-controlled, crossover trial on 45 young adults found that “Creatine supplementation had a significant positive effect on both working memory and intelligence, both tasks that require speed of processing”. [16]
A double-blind study at Penn State University concluded that “Creatine supplementation resulted in a significant improvement in peak power output during all 5 sets of jump squats and a significant improvement in repetitions during all 5 sets of bench presses”. [17]
An extensive rodent study conducted by 20 German scientists was published in the Neurobiology of Aging Journal in 2008. It concluded that “Creatine may be a promising food supplement to promote healthy human aging”. [18]
Himalayan Pink Salt (sodium chloride + trace minerals)
Creatine and sodium are “co-transporters”, meaning that creatine absorption is dependent on having adequate levels of sodium. [19-21] However people typically take creatine after working out when their body’s sodium levels are severely depleted (caused by sweating and electrolyte dilution from drinking a lot of water).
Himalayan Pink Salt is included in BioCreatine™ to optimize sodium levels for maximum creatine uptake.
Regarded as the highest quality and most nutrient-dense source of sodium on the planet, Himalayan Pink Salt contains more than 84 trace minerals and key electrolytes for optimal health and hydration.
A study examining the creatine transporter mechanism found that creatine is absorbed “predominantly by the way of a sodium-chloride dependent creatine transporter” and indicated that “combining creatine and sodium may additionally enhance creatine uptake.” [22]
When studying creatine uptake in skeletal muscle, researchers at the University of Missouri found that “the primary means to add creatine to muscle is uptake of creatine through the sodium-dependent creatine transporter.” [23]
A Scandinavian study concluded that creatine “uptake is largely Na+ (sodium) dependent in soleus muscle.” [24]
Fenugreek Seed Extract
In the mid-1990's it was discovered that creatine's muscle absorption could be significantly increased with high-glycemic carbohydrates (by simulating an insulin response). [25-29] Insulin assists in the transport of creatine and other nutrients into muscle cells. This is why most commercially available creatine products include sugar or some other form of carbohydrates.
Fenugreek Extract naturally activates the insulin receptor [30, 31], creating an effective way to improve creatine absorption without without having to consume carbohydrates. In fact research has shown that creatine + fenugreek is just as effective as creatine + carbohydrates. [32]
Fenugreek Extract also helps achieve peak performance by increasing testosterone [33, 34] and endurance. [35]
In a 2011 study on 47 men scientists found that “ingesting fenugreek in combination with creatine monohydrate may be an effective strategy for improving creatine uptake similarly to dextrose without having to ingest large amount of simple carbohydrates.” They also discovered “significant increases in bench press 1 rep max and lean mass”. [36]
Published in the International Journal of Sport Nutrition, a study conducted on 30 college-age men found that “500 mg of daily (fenugreek) supplementation significantly affected percent body fat, total testosterone, and bioavailable testosterone compared with a placebo in a double-blind fashion.” [37]
When studying the effect of fenugreek seed extract on endurance capacity in mice, Japanese researchers suggested that “improvement in swimming endurance by the administration of fenugreek is caused by the increase in utilization of fatty acids as an energy source” [38]
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Citations & References
1. Bessman, S. P., & Carpenter, C. L. (1985). The creatine-creatine phosphate energy shuttle. Annual review of biochemistry, 54(1), 831-862.
2. Wallimann, T., Tokarska-Schlattner, M., & Schlattner, U. (2011). The creatine kinase system and pleiotropic effects of creatine. Amino acids, 40(5), 1271-1296.
3. Becque, M. D., Lochmann, J. D., & Melrose, D. R. (2000). Effects of oral creatine supplementation on muscular strength and body composition. Medicine & Science in Sports & Exercise, 32(3), 654-658.
4. Volek, J. S., Kraemer, W. J., Bush, J. A., Boetes, M., Incledon, T., Clark, K. L., & Lynch, J. M. (1997). Creatine supplementation enhances muscular performance during high-intensity resistance exercise. Journal of the american dietetic association, 97(7), 765-770.
5. Kamber, M., Koster, M., Kreis, R., Walker, G., Boesch, C., & Hoppeler, H. (1999). Creatine supplementation--part I: performance, clinical chemistry, and muscle volume. Medicine and science in sports and exercise, 31(12), 1763-1769.
6. OOSTERLAAR, A. M., HARTGENS, F., HESSELINK, M. K., & WAGENMAKERS, A. J. (2003). Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans. Clinical science, 104(2), 153-162.
7. Rae, C., Digney, A. L., McEwan, S. R., & Bates, T. C. (2003). Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial. Proceedings of the Royal Society of London B: Biological Sciences, 270(1529), 2147-2150.
8. Ling, J., Kritikos, M., & Tiplady, B. (2009). Cognitive effects of creatine ethyl ester supplementation. Behavioural pharmacology, 20(8), 673-679.
9. Benton, D., & Donohoe, R. (2011). The influence of creatine supplementation on the cognitive functioning of vegetarians and omnivores. British journal of nutrition, 105(7), 1100-1105.
10. Benton, D., & Donohoe, R. (2011). The influence of creatine supplementation on the cognitive functioning of vegetarians and omnivores. British journal of nutrition, 105(7), 1100-1105.
11. Watanabe, A., Kato, N., & Kato, T. (2002). Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Neuroscience research, 42(4), 279-285.
12. Klein, A. M., & Ferrante, R. J. (2007). The neuroprotective role of creatine. In Creatine and Creatine Kinase in Health and Disease (pp. 205-243). Springer Netherlands.
13. Béard, E., & Braissant, O. (2010). Synthesis and transport of creatine in the CNS: importance for cerebral functions. Journal of neurochemistry, 115(2), 297-313.
14. Klopstock, T., Elstner, M., & Bender, A. (2011). Creatine in mouse models of neurodegeneration and aging. Amino acids, 40(5), 1297-1303.
15. Bender, A., Beckers, J., Schneider, I., Hölter, S. M., Haack, T., Ruthsatz, T., ... & Irmler, M. (2008). Creatine improves health and survival of mice. Neurobiology of aging, 29(9), 1404-1411.
16. Rae, C., Digney, A. L., McEwan, S. R., & Bates, T. C. (2003). Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial. Proceedings of the Royal Society of London B: Biological Sciences, 270(1529), 2147-2150.
17. Volek, J. S., Kraemer, W. J., Bush, J. A., Boetes, M., Incledon, T., Clark, K. L., & Lynch, J. M. (1997). Creatine supplementation enhances muscular performance during high-intensity resistance exercise. Journal of the american dietetic association, 97(7), 765-770.
18. Bender, A., Beckers, J., Schneider, I., Hölter, S. M., Haack, T., Ruthsatz, T., ... & Irmler, M. (2008). Creatine improves health and survival of mice. Neurobiology of aging, 29(9), 1404-1411.
19. Schoch, R. D., Willoughby, D., & Greenwood, M. (2006). The regulation and expression of the creatine transporter: a brief review of creatine supplementation in humans and animals. Journal of the International Society of Sports Nutrition, 3(1), 60.
20. Willott, C. A., Young, M. E., Leighton, B., Kemp, G. J., Boehm, E. A., Radda, G. K., & Clarke, K. (1999). Creatine uptake in isolated soleus muscle: kinetics and dependence on sodium, but not on insulin. Acta physiologica scandinavica, 166(2), 99-104.
21. Brault, J. J., & Terjung, R. L. (2003). Creatine uptake and creatine transporter expression among rat skeletal muscle fiber types. American Journal of Physiology-Cell Physiology, 284(6), C1481-C1489.
22. Schoch, R. D., Willoughby, D., & Greenwood, M. (2006). The regulation and expression of the creatine transporter: a brief review of creatine supplementation in humans and animals. Journal of the International Society of Sports Nutrition, 3(1), 60.
23. Brault, J. J., & Terjung, R. L. (2003). Creatine uptake and creatine transporter expression among rat skeletal muscle fiber types. American Journal of Physiology-Cell Physiology, 284(6), C1481-C1489.
24. Willott, C. A., Young, M. E., Leighton, B., Kemp, G. J., Boehm, E. A., Radda, G. K., & Clarke, K. (1999). Creatine uptake in isolated soleus muscle: kinetics and dependence on sodium, but not on insulin. Acta physiologica scandinavica, 166(2), 99-104.
25. Green, A. L., Hultman, E., Macdonald, I. A., Sewell, D. A., & Greenhaff, P. L. (1996). Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. American Journal of Physiology-Endocrinology And Metabolism, 271(5), E821-E826.
26. Green, A. L., Simpson, E. J., Littlewood, J. J., Macdonald, I. A., & Greenhaff, P. L. (1996). Carbohydrate ingestion augments creatine retention during creatine feeding in humans. Acta Physiologica, 158(2), 195-202.
27. Steenge, G. R., Lambourne, J., Casey, A., Macdonald, I. A., & Greenhaff, P. L. (1998). Stimulatory effect of insulin on creatine accumulation in human skeletal muscle. American Journal of Physiology-Endocrinology And Metabolism, 275(6), E974-E979.
28. Steenge, G. R., Simpson, E. J., & Greenhaff, P. L. (2000). Protein-and carbohydrate-induced augmentation of whole body creatine retention in humans. Journal of Applied Physiology, 89(3), 1165-1171.
29. Pittas, G., Hazell, M. D., Simpson, E. J., & Greenhaff, P. L. (2010). Optimization of insulin-mediated creatine retention during creatine feeding in humans. Journal of sports sciences, 28(1), 67-74.
30. Vijayakumar, M. V., Singh, S., Chhipa, R. R., & Bhat, M. K. (2005). The hypoglycaemic activity of fenugreek seed extract is mediated through the stimulation of an insulin signalling pathway. British journal of pharmacology, 146(1), 41-48.
31. Baquer, N. Z., Kumar, P., Taha, A., Kale, R. K., Cowsik, S. M., & McLean, P. (2011). Metabolic and molecular action of Trigonella foenum-graecum (fenugreek) and trace metals in experimental diabetic tissues. Journal of biosciences, 36(2), 383-396.
32. Taylor, L., Poole, C., Pena, E., Lewing, M., Kreider, R., Foster, C., & Wilborn, C. (2011). Effects of combined creatine plus fenugreek extract vs. creatine plus carbohydrate supplementation on resistance training adaptations. Journal of sports science & medicine, 10(2), 254.
33. Wilborn, C., Taylor, L., Poole, C., Foster, C., Willoughby, D., & Kreider, R. (2010). Effects of a purported aromatase and 5 α-reductase inhibitor on hormone profiles in college-age men. International journal of sport nutrition and exercise metabolism, 20(6), 457-465.
34. Steels, E., Rao, A., & Vitetta, L. (2011). Physiological Aspects of Male Libido Enhanced by Standardized Trigonella foenum‐graecum Extract and Mineral Formulation. Phytotherapy Research, 25(9), 1294-1300.
35. Ikeuchi, M., Yamaguchi, K., Koyama, T., Sono, Y., & Yazawa, K. (2006). Effects of fenugreek seeds (Trigonella foenum greaecum) extract on endurance capacity in mice. Journal of nutritional science and vitaminology, 52(4), 287-292.
36. Taylor, L., Poole, C., Pena, E., Lewing, M., Kreider, R., Foster, C., & Wilborn, C. (2011). Effects of combined creatine plus fenugreek extract vs. creatine plus carbohydrate supplementation on resistance training adaptations. Journal of sports science & medicine, 10(2), 254.
37. Wilborn, C., Taylor, L., Poole, C., Foster, C., Willoughby, D., & Kreider, R. (2010). Effects of a purported aromatase and 5 α-reductase inhibitor on hormone profiles in college-age men. International journal of sport nutrition and exercise metabolism, 20(6), 457-465.
38. Ikeuchi, M., Yamaguchi, K., Koyama, T., Sono, Y., & Yazawa, K. (2006). Effects of fenugreek seeds (Trigonella foenum greaecum) extract on endurance capacity in mice. Journal of nutritional science and vitaminology, 52(4), 287-292.