Brainbiotic™ is premium blend of probiotic strains designed to support the gut - brain axis. Research suggests that the probiotic strains in Brainbiotic™ are associated with increased brain-derived neurotrophic factor (BDNF), memory enhancement, and relief of stress-related symptoms.†
Gut-Brain Axis Optimizer
Defeat Brain Fog
Take 1-2 capsules per day, or as directed by a healthcare practitioner.
The microbiome is essential to health, immune function, and plays a major role in the communication between the gut and the brain. Over the past few years scientists have begun to understand the importance of the microbiome in the context of brain function. Studies show that the gut-brain axis (gut-brain connection) is deeply linked with numerous aspects of cognition including mood, memory, and brain health. By targeting the gut-brain axis with key probiotic strains we’re able to activate a positive immune response in the brain while improving cognitive function at any stage of life.
Probiotics are the healthy microbes our gut needs to function at its best. Within the gut is a vast and diverse “rainforest” of hundreds of different bacterial organisms. Over the past 5 years over 4,000 studies have investigated the link between the health of the gut microbiome and the health of the human brain. We’ve long known the gut’s role in immune function and digestion, but only in recent years have scientists discovered the powerful connection between gut and mind. Of all the studies looking at the gut-brain axis, researchers have identified 4 key strains that have been proven to unlock benefits related to mood, memory, brain health, and higher level cognitive functions.
With the probiotics found in Brainbiotic™ you can support your brain while supporting your gut at the sametime.
L. Plantarum is a beneficial and versatile probiotic strain, able to survive stomach acid with ease, allowing it to reach the colon fully active and intact. Here, the probiotic strain is effective at maintaining, restoring, and balancing the gut microbiota.
Studies have shown that L. Plantarum can support long-term memory by increasing levels of the all-star brain growth hormone, brain-derived neurotrophic factor (BDNF). The culture has also been shown to improve cognitive abilities in rats by lowering pressure and exerting neuroprotective properties in brain cells. 
Regular consumption of L. Plantarum may also reduce anxiety. The strain was found to increase levels of dopamine and serotonin while reducing anxiety symptoms, depressive symptoms, and inflammatory cytokines associated with mental and physical stress. [2 3]
L. Plantarum also plays a key role in regulating inflammation. Daily supplementation was found to reduce production of inflammatory cytokines and reduce oxidative stress in animal models .
L. Plantarum supports the health and survival of brain cells by suppressing activation of the protein NF-κB, the single most important regulator of inflammation in the body and brain. NF-κB inhibition is linked with brain growth and development. More specifically, inhibition of this protein is associated with improved learning, intelligence, neural plasticity, and memory. synaptic plasticity, BDNF levels are also increased, which enhances cognitive function and the growth of new neurons. [5, 6, 7]
L. Brevis is one of the most well-studied probiotic strains known to influence human health and cognition. The predominant culture in sauerkraut and pickled vegetables, this strain is well known to increase immune function and fight bacterial infection, in addition to its unique effects on the central nervous system.
L. Brevis provides support against inflammatory compounds associated with impaired memory and cognitive decline. It is one of the essential probiotics for brain health because it increases levels of BDNF, the brain’s all-star growth hormone that controls the health and growth of new neurons. In one study, old rats were given L. Brevis and young rats were given a placebo. The results found that in addition to lowering inflammatory markers TNF, IL1β, and NF-κB L. Brevis significantly increased expression of BDNF to levels greater than the healthy young rats. 
This suggests that L. Brevis may restore healthy brain function in elderly populations, possibly to levels greater than healthy young individuals.
L. Brevis has also been shown to have a positive effect on reducing anxiety, depressive symptoms, and restoring a positive mood. 
Lactobacillus Helveticus & Bifidobacterium Longum
These are two of the most effective probiotic strains to promote a positive mood, reduce stress, and relieve anxiety and depressive symptoms.
In one study, consuming a mixture of three Lactobacillus and Bifidobacteria strains for eight weeks significantly reduced depressive symptoms. The probiotic also reduced inflammation in the patients. 
A handful of other studies have examined how probiotics affect depressive symptoms in healthy subjects. In healthy people these strains have been found to reduce:
Symptoms of anxiety [11, 12, 13]
Depressive symptoms 
Psychological distress 
Academic stress 
Researchers also found that taking probiotics reduced participants’ negative thoughts associated with a sad mood. 
Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas and ingredient suppliers in an open source format.
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